The Best Enzyme Cleaners

Cleaning up after pet messes is just one of the hassles of pet ownership, but it doesn’t have to be a dealbreaker. Part of getting a good cleaning has the right tools, and if you’re looking for a better way to remove stains, you’re in the right place. With enzyme cleaners, you can break down stains with organic fighting power, making for more effortless cleaning. That’s why we’ve narrowed down the best enzyme cleaners on the market to help you keep your home spick and span. Just give it a spray and let these cleaners do the heavy lifting.

What to Look For

When narrowing down the best enzyme cleaners on the market, we considered size, cleaning power, ingredients, and price. For example, if you want a well-rounded cleaner that offers strong stain-fighting power at a reasonable price, the Rocco & Roxie Supply Co. enzyme pet odor eliminator is a great option. If you want to stock up and buy in bulk, Bubba’s Rowdy Friends super strength enzyme cleaner offers an entire gallon of cleaning solution for the toughest stains. Read on to see all our top picks and find the enzyme cleaner that’s right for you.

Rocco & Roxie Supply Co. Enzyme Pet Odor Eliminator

Do it all

This well-rounded stain fighter has a potent formula and works on just about everything.
Best Overall

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If you’re not sure where to begin your search for an enzyme cleaner, this cleaning solution from Rocco & Roxie Supply Co. is a great place to start. It has a manageable size, an easy-to-use bottle design, and a solution that works on virtually every surface imaginable. It can cover clothing, carpets, hardwood, upholstery, tile, and even tricky surfaces like concrete and artificial grass. It has built-in enzymes that feed on organic material like ammonia crystals found in cat urine, and it continues to break them down after contact. On top of its strong formula, it’s fit for everyday use for all kinds of messes, from pet stains to laundry. No matter what you need it for, this enzyme cleaning solution is effective for just about everything, making it a great value.


  • Reasonable price
  • Works for laundry
  • Erases scents instead of covering them up
  • Feeds on ammonia crystals and organic matter
  • Even works on surfaces like concrete and artificial grass


  • Requires vacuuming to work properly

Bubba’s Rowdy Friends Super Strength Enzyme Cleaner

Bigger and better

This gallon of cleaning solution has a tried and true formula that's made to take on the most challenging stains time after time.
Best Bulk Buy

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For households with a lot of pets, you may end up going through a lot of cleaning products. If you’re looking to stock up for the long haul, this gallon of super-strength cleaner goes a long way. With a hardworking formula that starts eliminating stains on contact, this cleaner has a bio-enzymatic recipe that doesn’t stop eradicating the mess until it’s completely gone. In fact, the solution is so strong it even works on blood and sweat stains, so it’s great for human messes too. Whether you want a strong formula for everyday use or a long-lasting bulk buy, this cleaner is fit for the job.


  • Safe for all carpets
  • Quantity goes a long way
  • Even works on blood and sweat stains
  • Stronger formula than much of the competition


  • Fairly expensive

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner

Don't break the bank

Fight stains all around the house at a low price with this versatile, everyday cleaning solution.
Best On A Budget

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If you’re on a tight budget and you need a multi-purpose enzyme cleaner, you’ve come to the right place. This versatile cleaner is meant for more than just carpets and floors. You can pour it down the drain to break down organic buildup from hair and food particles, use it in the kitchen to fight grease and oil, or spray it in the bathroom for all kinds of spills. It’s great for pet stains and even comes in a variety of different scents to fit your preferences. This concentrated formula is here to fight whatever stains come your way. Best of all, it comes at a great price. Just point, spray, and let this enzyme-enriched solution do the rest.


  • Comes in five different scents
  • Great price
  • Prevents clogs in drains
  • Works on floors, pipes, kitchens, and bathrooms
  • Manageable size


  • Scents may smell more harsh than fragrant

Biokleen Bac-Out Stain Remover

All natural

This eco-friendly option provides strong cleaning power without any harsh chemicals.
Best Plant-Based

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If you want to avoid harsh chemicals at all costs, this stain remover from Biokleen may be the natural solution for you. This eco-friendly cleaner contains a plant-based solution that’s safe around pets, making it great for use around the house. While it’s not solely made for animal stains, it has live, hardworking enzyme cultures that absorb organic material, so it works effectively against all kinds of organic fluids. It fights against pet and human stains alike, and at 128 ounces, there’s more than enough to go around. If you want to give the chemicals a break and make way for something more pet-friendly, this stain remover is about as natural as it gets.


  • No artificial fragrances or dyes
  • Never tested on animals
  • Great at absorbing organic material
  • Works for human messes as well as animal ones
  • Great for clothes


  • Not as good at removing smells as other formulas

Angry Orange Enzyme Pet Cleaner

Freshly squeezed

Tackle all your toughest stains and smells with this orange-scented, heavy-duty stain remover.
Most Powerful

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If you’re looking for strong stain-fighting power with an even stronger scent to back it up, look no further. This powerful spray from Angry Orange packs a big punch that makes taking down stains a breeze. With each application, this spray uses a dual-action solution to remove stains and annihilate the scent with a powerful orange fragrance, creating a fresh new smell for up to 80 hours of coverage. Unlike other sprays out there, this pet cleaner uses a citrus aroma instead of a chemical or perfume-based scent for a bold new blast of zesty goodness. For the biggest stains and the strongest smells, this enzyme cleaner is ready for the mess.


  • Dual-action solution
  • Lasts for up to 80 hours of freshness
  • Powerful citrus scent
  • Works on almost every possible surface
  • Doesn’t smell like chemicals or perfume


  • The scent may be too overpowering for some users

Frequently Asked Questions

Are enzyme cleaners just for pet stains?

Actually, no. Many popular cleaning products contain enzymes to help break down stains. For example, OxiClean laundry detergent and Dawn Platinum dish soap both contain enzymes to help eliminate stains. They aren’t directly marketed as enzyme cleaners, but they still use the natural power of enzymes to help with removing stains. However, enzymes can be especially helpful in neutralizing pet stains and odors.

What are enzymes?

To simplify, enzymes are naturally occurring proteins that can be combined with other elements to produce a chemical reaction. In our bodies, they can speed up our metabolism and break down (or build up) the substances in our bodies. In the cleaning world, enzymes can be used to create a chemical reaction with other ingredients that helps break down tough stains.

About the Author

Mitchell is a proud dad of two rescued feral cats, and he is very fond of their curious nature. He knows that it takes some time for cats to open up to their humans, and he knows exactly how daunting it can be to be a first time cat owner. He hopes to share his expertise and his experiences with his own cats with other cat owners so they can give their pets happy, healthy lives.

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Since 2008, CatTime has provided millions of cat owners with all the information they need to keep their pets happy and healthy. Our experts know exactly what it takes to raise our furry friends and our goal is to help all owners, new or experienced, care for their cats with all the right food, toys, equipment, and accessories.